UPDATED, 8:53 p.m., EDT---Flooding closed Interstate 44 at mile marker 172 near the city of Jerome early Wednesday morning. In addition, Route 63 is now closed in two locations: south of Vienna in Maries County and at Westphalia in Osage County, further complicating detour routes, according to the Missori Department of Transportation.

Motorists are encouraged to use U.S. 60, I-70 or U.S. 36 as alternate routes. This is especially important for commercial motor vehicle traffic approaching Missouri from other states.

National Weather Service predictions indicate water will overtake the lanes of U.S. 50 at Mount Sterling by mid-morning on Thursday, making travel in the area even more difficult.

"We don't know for certain when flooded roadways will reopen or what additional flooding might occur," said Travis Koestner, assistant district engineer of the Missouri Department of Transportation, Central District.

When the water recedes, MoDOT will inspect pavement and bridges for safety before opening highways for public use.

Drivers and dispatchers are advised check MoDOT's Traveler Information Map, located at http://www.modot.org/ or call the departments toll free number at 1-888-ASK-MODOT, to get updated on road conditions.